Relationship analysis of drug side effects with "visual grouping method" added to "Association analysis"
SAS Institute Japan Corporation JMP Japan Division System Engineer Masahiro Masukawa
Association analysis is used as a method to find strong associations among combinations of products purchased by a consumer at a store, but it can also be applied to a method of finding a side effect pattern of a drug.By this analysis, it is possible to know a combination of side effects that is likely to occur to a patient who has given a certain drug.In JMP Pro 13 there is a platform of "association analysis", even with a large amount of side effects data of various types, an a priori algorithm presents a combination of frequent side effects.In addition, on this platform, there is an option to singular value decompose (SVD) the matrix of transaction (patient) and item (side effect), and by drawing the matrix down to low dimension, the occurrence pattern of side effects is similar Grouping patients and side effects themselves can be grouped visually.Although singular value decomposition is a grouping method different from association analysis, there are cases where it is possible to find relevance that can not be found by association analysis, and it is beneficial to combine both analyzes and consider the result.In this presentation, using the drug side effect database (JADER) published by the Pharmaceuticals and Medical Devices Agency (PMDA), on the "Association Analysis" platform, the relevance of side effects for patients who administered certain drugs We present an example of analysis and demonstrate the usefulness of considering the singular value decomposition report.
