In this presentation, we will attempt to compare and analyze two major methodologies, Response Surface Methodology (RSM) and Taguchi Method, which are mainly used in the field of Design of Experiments (DOE), using JMP. We will analyze the characteristics, advantages and disadvantages of the two methods, and the suitability and efficiency of each method using JMP, and present the optimal selection criteria in DOE. Through this comparison, researchers and practitioners will be able to more clearly understand the applicability and effectiveness of each method.