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Clinical trial design

A university researcher has asked if JMP has clinical trial design capabilities (e.g., permuted block designs, stratified randomization, minimization methods). From what I know, neither JMP (Pro) nor JMP Clinical have dedicated clinical trial design tools, but perhaps the existing DOE tools or others could provide an indirect route. For example: stratified randomization can be achieved with Make Validation Column, and maybe the Custom Designer (or MSA Design?) could spit out something akin to a permuted block design. I really don't know enough about clinical trial designs to say anything for sure.

Anybody have recommendations for designing clinical trials in JMP? (And maybe the advice is: "don't".) @Chris_Kirchberg?

Re: Clinical trial design

Hi @Ross_Metusalem ,

There is nothing specific in JMP or JMP Clinical for designing Clinical Trials. There are schemes that do not exist in our DOE platform that are addressed in other tools. Here is just one of them: https://www.trialdesign.org/#newsSection

Sorry we do not have much more in this area to help.

Re: Clinical trial design

Thanks, @karencopeland. You're right that the specific techniques mentioned really are just about sequential random assignment. I'll be talking with this faculty member again soon and will ask for more detail to see if this is really all they need. As you say, it'd be easy enough to tackle just this aspect in JMP even without dedicated tools.

Re: Clinical trial design

Thanks, Chris. Luckily this is not any kind of deal-breaker here. I'll pass word along to the user.

Re: Clinical trial design

Agreed with Chris that there is nothing specific in JMP to design a clinical trial. However, the question being asked of you appears to be about subject randomization tools as opposed to trial design.  Not sure what they mean by minimization methods. However, I believe that when they ask about permuted block designs and stratified randomization this has to do with assignment of treatments to subjects as they are enrolled (pre-defined random but controlled random assignments).  So they are asking about a "part" of clinical trial design. When someone asks you an open ended type question fire back with more questions.  As you said, this is not an area of your expertise, so ask for more details. The stats part of trial design is just part of it and again, your question was only about a tiny (easy) part of the stats part.  Reach out if you have other questions. I haven't designed drug trials but have device, sample collection, and diagnostic trials.