This may seem like a really obscure question, but I actually think at least a decent number of biologists deal with this: sacrificing organisms during the study. I have used some of the platforms under "reliability and survival" under "Analyze," and they are well set up for situations in which your sample size inherently decreases over the duration of your study because you are either removing organisms for analyses or they are dying due to the treatment. What I am wondering is: can JMP's DOE platform be used for setting up such experiments? From playing around with it today, it seems like you would have to manually enter in "constraints" (e.g., genotype A will NOT be there at time point X because it would have already been removed.) but then again you may not actually know ahead of time when and under which situations an experimental organism may die and therefore cease to serve as a replicate. Are there dedicated DOE platforms for these sorts of studies? Toxicologists much use them, and I imagine others may, as well.
