Mason Chen, Student, Stanford OHS
Patrick Giuliano, Senior Analytical Technical Support Engineer, JMP
Charles Chen, Advisor, STEAMS
This presentation demonstrates how to design a HIIT (High-Intensity Interval Training) profile to help a type 2 diabetes patient avoid insulin glargine injections. In addition to meal control and taking metformin and/or insulin, diabetes patients should exercise at a higher heart rate to burn sugar faster.
A full factorial DOE of treadmill settings (incline and speed) was conducted to build a heart rate RSM model to design the optimal HIIT profile. Based on the RSM model, interaction effects were all very small, which may indicate the treadmill heart rate model is not coupling (complicate). Heart rate is linearly proportional to incline level (potential energy when incline angle is small) and in quadratic form with speed (kinetic energy). To avoid injury to the knee/foot and ACL (anterior cruciate ligament), jumping patterns were studied using 3D motion biomechanics modeling. The fatigued muscles could not hold the knee stable or provide sufficient knee cushion during the shorter soft landing, which could increase the risk of an ACL injury during the second hard landing period.
By using the Model Driven SPC, the injury mechanism was studied to determine the treadmill's highest speed limit for this diabetes patient. Through these ACL risk studies, the HIIT profile has been further optimized to consider these ACL design constraints. By following the HIIT profile that was designed with JMP, this diabetic patient has seen significant reduction of blood glucose levels and serum readings (falling from over 200 mg/dL to near 75 mg/dL) in four months.
