Profile -likelihood CIs for risk ratiosProportional Hazards Fit provides profile likelihood based confidence intervals for the Parameter Estimates. Please provide this type of CIs also for the Risk Ratios; this is important because the risk ratios are the usual measure of effect size in survival analysis.
Reliability AnalysisRe: Profile -likelihood CIs for risk ratios - Status changed to: Acknowledged@winfriedkoch0 thank you for this new feature idea. We are evaluating this idea as a possible future improvement to JMP.
Re: Profile -likelihood CIs for risk ratios - Status changed to: InvestigatingRe: Profile -likelihood CIs for risk ratios - Status changed to: Needs Info@winfriedkoch0 we have investigated this request, and I wanted to let you know that we do calculate and report Wald confidence intervals for risk ratios (hazard ratios) in Fit Proportional Hazards. These confidence intervals use normal approximations for the confidence limits. Does this meet your needs?
( output from example data VA Lung Cancer)
Risk Ratios
Unit Risk Ratios
Per unit change in regressor
Term
|
Risk Ratio
|
Lower 95%
|
Upper 95%
|
Reciprocal
|
Age
|
0.991487
|
0.9739
|
1.010136
|
1.0085861
|
Diag Time
|
0.999908
|
0.979971
|
1.016244
|
1.000092
|
KPS
|
0.967905
|
0.957488
|
0.978403
|
1.0331596
|
Range Risk Ratios
Per change in regressor over entire range
Term
|
Risk Ratio
|
Lower 95%
|
Upper 95%
|
Reciprocal
|
Age
|
0.669099
|
0.288517
|
1.606371
|
1.4945466
|
Diag Time
|
0.992119
|
0.175518
|
3.998028
|
1.0079435
|
KPS
|
0.05484
|
0.020935
|
0.143244
|
18.23482
|
Risk Ratios for Cell Type
Level1
|
/Level2
|
Risk Ratio
|
Prob>Chisq
|
Lower 95%
|
Upper 95%
|
Large
|
Adeno
|
0.4544481
|
0.0092*
|
0.2511038
|
0.8224612
|
Small
|
Adeno
|
0.7176217
|
0.2286
|
0.4181316
|
1.2316242
|
Squamous
|
Adeno
|
0.3047391
|
<.0001*
|
0.1690124
|
0.5494621
|
Small
|
Large
|
1.579106
|
0.0862
|
0.9370433
|
2.6611104
|
Squamous
|
Large
|
0.6705696
|
0.1574
|
0.3853373
|
1.166935
|
Adeno
|
Large
|
2.2004712
|
0.0092*
|
1.2158629
|
3.9824176
|
Squamous
|
Small
|
0.4246514
|
0.0019*
|
0.2476225
|
0.7282408
|
Adeno
|
Small
|
1.3934918
|
0.2286
|
0.811936
|
2.3915917
|
Large
|
Small
|
0.6332697
|
0.0862
|
0.375783
|
1.0671865
|
Adeno
|
Squamous
|
3.2814957
|
<.0001*
|
1.8199618
|
5.916725
|
Large
|
Squamous
|
1.4912695
|
0.1574
|
0.8569458
|
2.5951289
|
Small
|
Squamous
|
2.3548727
|
0.0019*
|
1.3731721
|
4.0384051
|
Risk Ratios for Treatment
Level1
|
/Level2
|
Risk Ratio
|
Prob>Chisq
|
Lower 95%
|
Upper 95%
|
Test
|
Standard
|
1.3363418
|
0.1617
|
0.8903074
|
2.0058347
|
Standard
|
Test
|
0.7483115
|
0.1617
|
0.4985456
|
1.1232076
|
Risk Ratios for Prior
Level1
|
/Level2
|
Risk Ratio
|
Prob>Chisq
|
Lower 95%
|
Upper 95%
|
Yes
|
No
|
1.0750063
|
0.7554
|
0.6820551
|
1.6943478
|
No
|
Yes
|
0.9302271
|
0.7554
|
0.5901976
|
1.4661572
|
Re: Profile -likelihood CIs for risk ratios - Status changed to: DeliveredBased on additional communication, the Wald confidence intervals are sufficient to meet this need. Thank you for your suggestion and continued engagement with JMP!
