Setting up an screening designHi,
we are currently trying to set up our first custom design but are struggling with the choices. Our problem is that we have 4 groups of factors: 1st group has 2 options, 2nd group 3 factors, 3rd group 4 factors and the 4th group only one factor - so in total 10 factors but they are continuous values. This is where we struggle to set it up. If they would be only categorical then we would just add categorical factors with certain amount of levels.
What we already know from previous experiments:
- The concentration of each factor has a quadratic effect on the outcome. Meaning we do not only need to check the interactions but also check the interactions at different concentrations.
- Only different factors of the 3rd group should be present at the same time in a run. Thus, we would need to set up constraints to not allow combinations of the 2 factors of the 1st group or the 3 factors of the 2nd group.
I tried a custom design where I added the 10 factors as continuous factors. Then I set up under "Define Factor Constraints" and "Use Disallowed Combinations Filter": factor 1 AND factor 2 (of group 1) OR factor 1 AND factor 2 AND factor 3 (of group 2). I made sure that the min and max values are included but what I cannot understand is that when adding the 2nd interactions the interaction factor 1*factor 2 is included as well as other combinations. So I think there is already an error.
I did not know how to get rid of these unwanted interactions so I took the time to remove them manually from the list of 2nd and 3rd interactions but anyway these combinations are included after I continue to the table.
How do I proceed with the design?
Thanks.
DOERe: Setting up an screening designWhy are the factors grouped? What is the meaning or purpose of each group?
Do you mean that only one factor from group 1 and group 2 may be present but more than one factor in group 3 may be present?
Is the concentration range for the factors in each group the same?
Re: Setting up an screening designWelcome to the community. I've read your post and I will have to admit, without understanding the situation better it is difficult to provide specific advice. I have some questions/comments:
1. How do you know there are quadratic effects? Usually when we do screening, we are looking to develop models following scarcity and hierarchy principles.
2. I'm not sure what a "group" is? Is this experiment on sequential steps of a process? If so, you may be able to take advantage of split-plot designs.
3. Since you suspect non-linear effects, perhaps use a definitive screening design to start with?
4. Are you trying to economize the experiment significantly? If not, perhaps the effects estimated for the interactions that are non-sensical can be used to estimate the MSE?
Personally, I believe in sequential experimentation. I follow the KISS principle (Keep It Simple and Sequential). Don't try to get too much from any one experiment. Ensure your experiment provides guidance for setting up the next experiment. Screening designs are intended to help start the journey.
Re: Setting up an screening designThank you for the answer statman.
It might be worth mentioning that there is no need for any factor to be present but to figure out which factor to include and at what amount. To answer your questions and specify the problem:
1. We run some preliminary experiments where we included only one factor and saw that there is a quadratic response. Now I thought that this is true if you screen combinations. Do you think that I should use the best conditions for each factor determined in the single factor screen to get an understanding on the interactions? I would assume that the best condition for a single factor is not necessarily the best condition when you combine it with different factors.
2. A group is a set of factors that share the same properties and in case of 2 groups cannot be combined.
3. I am not sure how this would help me on restricting certain combinations.
4. No, actually you are right. That is a good idea.
I think the main problem with setting up the design is that I want to have two levels at the same time: I want to figure out the most important factors of each group and how they interact but at the same time figure out how they interact at different concentrations. Secondly, I do not want to have every factor present in each run.
Re: Setting up an screening designHi markbailey,
also thank you for your answer.
Why are the factors grouped? What is the meaning or purpose of each group?
The factors are grouped due to similar properties and due to the fact that I can only include 1 factor of each group except for group 3. Yes
Do you mean that only one factor from group 1 and group 2 may be present but more than one factor in group 3 may be present?
Yes, exactly.
Is the concentration range for the factors in each group the same?
No, some differ by a factor of 100.
