Hi all,
I had a customer ask whether it is possible to include some factor that accounts for variation between donors.
Here's the situation:
It's a biotech company developing treatments and analysis methods. They use donor cells to develop some method on. These cells are from an unknown donor. Afterwards they apply the results to cells from other donors/patients.
Since every donor is different, they expect to have variability in the final result from donor to donor/patient.
But when they do the method development, they only have a single source of cells, so they cannot include a factor "donor".
Not sure if I just don't see the solution...
Anybody recognize the situation and know how this is typically handled?
Happy about any feedback!
Best
Florian
Hi Florian,
They would definitely need to use material from multiple donors in their development process in order to model donor-to-donor variability. With just a single donor, there's no way to know.
Andrew Karl and Heath Rushing had a nice presentation on this topic at US Discovery this year:
Biopharmaceuticals' New Frontier: Modeling Patient/Donor Variability for Gene/Cell Therapy in JMP (2021-US-30MP-887)
Jordan
