Hello!
Just curious why we see different results in such cases.
Here we have a classic 2-factor 2-level factorial design which we can analyze using Nominal regression/logistic regression.

Analysis shows that only interaction is significant :

However, if we transform this data as if there were 4 factors A1, B1, C (A1*B1), D (A0*B0),

then we will see that main effects are significant?

How can we explain and interpret this?
PS
Datasets are in attachments. These results are from real experiment.
You do not really have four factors. Your construction over-specifies the model, so JMP arbitrarily zeros the last 'factor' and indicates that the first three are biased.
The equivalent to two two-level factors would be one four-level factor, not four two-level factors.
I am sorry.
I have corrected the file to 1-factor 4-level. Now it shows that level A (which is factor A) is significant:
