What is the difference between a D-Optimal and I-Optimal designed experiment and when should you use one over the other?In his Basic Design of Experiments Mastering JMP session, Bill Worley @Bill_Worley suggests using D-Optimal if you want the best parameter estimates for the model. Use I-Optimal for the lowest prediction variance. If you think there is curvature, consider using I-Optimal, which will force mid-points into the design.
Use D-Optimal if you want best parameter estimates for the model; I-Optimal for lowest prediction variance. If you think there is curvature, consider using I-Optimal, which will force mid-points into the design.

Design of Experiments