I am using JMP 14.3.0 on Windows 10.
I am unable to remove the keyboard shortcut for file-save (CTRL-S). When I remove the keyboard shortcut via View-Customize->Menus and Toolbars->File->Save, the keyboard shortcut still works. When I re-assign CTRL-S to a different command, it does not run the command I reassigned it to, and instead still just does File->Save.
I was able to remove the shortcut for File-Save in JMP 13. So, it appears that this feature was broken in going from JMP 13 to JMP 14. I have not checked if other default keyboard shortcuts are also afflicted with the problem.
I have restarted JMP, and even after I restart JMP, the new keyboard short cut does not take.