I use SAS JMP to run multivariate testing experiments (MVT, regression), it generates a test plan and performs regression analysis, defining significant effects. The most important thing is to be able to interpret and know the pitfalls.
Mathematical calculations, as such, are not needed.
I have read statistics books such as Montgomery Design of experiments and they are usually full of formulas.
I still cannot understand how are they used in real world.
Yea I understand that I need to know concepts, different types of designs, basics of statistics as p value, standard deviation, how to calculate proper sample size, etc.
I speak about design of experiments mostly in web marketing and user experience fields.