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Pharmacokinetic Deconvolution

Hey!  I got asked by a customer about doing PK deconvolution in JMP.  I know we can fit PK models, but I wanted to see if any of the biochem / pharma experts had any examples of doing a PK deconvolution.

 

Thoughts?

 

M

Re: Pharmacokinetic DeconvolutionLet me get some additional data from the customer. Maybe I can get enough information to pull together a cohesive request.

M
Re: Pharmacokinetic Deconvolution

Clay and Chris designed Fit Curve to accept new models without much hassle. It is "hard coded" unlike Nonlinear and the script-based Model Library but much better in my opinion. They told me to let them know about additional models and recognize that the PK section is pretty light.

Re: Pharmacokinetic Deconvolution

Thanks, guys - looks like the short answer is that if they've got the equation we can do it using Fit Curve/Nonlinear.  (That appears to be the approach that the SAS macro was using... Though he should really have done a better job with his pseudocode... That sucker is hard to read!)

 

I think that's the case in this instance, but I wonder if this shouldn't be something we consider adding in some fashion... 

 

Thanks again!

 

M

Re: Pharmacokinetic Deconvolution

From FDA Guidance page 21:

 

Deconvolution: Estimation of the time course of drug input (usually in vivo absorption or dissolution) using a mathematical model based on the convolution integral. For example, the 22 absorption rate time course (r ) that resulted in the plasma concentrations (c(t)) may be abs estimated by solving the following convolution integral equation for r : abs

c(t) = I c (t-u) r (u) du

 

The function c represents the concentration time course that would result from the instantaneous * absorption of a unit amount of drug and is typically estimated from either i.v. bolus data, oral solution, suspension or rapidly releasing (in vivo) immediate release dosage forms.

 

Source: https://www.fda.gov/downloads/drugs/guidances/ucm070239.pdf

 

Also the reference Pete gave.

 

And a link to a paper discussing two different methods: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627461/#CR1

 

I think you would have to integrate the equation or make a version that Non-linear could use.

Re: Pharmacokinetic Deconvolution

Hey Mike,

 

Here is a PK deconvolution example from SAS.

 

https://www.lexjansen.com/pharmasug/2006/Posters/PO11.pdf

 

Re: Pharmacokinetic Deconvolution

Not I.

 

If no one else has any, I would expect on-line course materials for PK might have some examples that you could use.

Re: Pharmacokinetic Deconvolution

Here is a link to an online tutorial from NIH that contains an xlsx file of an example data set for PK analysis and some instructions for using R to do it. May not be the type of analysis requested, but a PK data set to look at.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372427/#cts13305-supitem-0001